accuracy of estrogen and progesterone receptor assessment in core needle biopsy specimens of breast cancer

Authors

ramesh omranipour cancer research center, cancer institute, tehran university of medical sciences, tehran, ir iran; department of surgery, cancer institute, tehran university of medical sciences, tehran, ir iran

sadaf alipour cancer research center, cancer institute, tehran university of medical sciences, tehran, ir iran; department of surgery, arash women’s hospital, tehran university of medical sciences, tehran, ir iran; 36 ebn ali street, north majidieh street, ressalat street. tehran, ir iran. tel: +98-2122507213, fax: +98-2177883196

maryam hadji cancer research center, cancer institute, tehran university of medical sciences, tehran, ir iran

forouzandeh fereidooni department of pathology, cancer institute, tehran university of medical sciences, tehran ir iran

abstract

objectives we undertook this study to compare the results of hormone receptor assessment in cnb and surgical samples on our patients. patients and methods hormone receptor status was determined in cnb and surgical samples in breast cancer patients whose cnb and operation had been performed in this institute from 2009 to 2011 and had not undergone neoadjuvant chemotherapy. results about 350 patients, 60 cases met all the criteria for entering the study. the mean age was 49.8 years. considering a confidence interval (ci) of 95%, the sensitivity of er and pr assessment in cnb was 92.9% and 81%, respectively and the specificity of both was 100%. the accuracy of cnb was 98% for er and 93% for pr. conclusions our results confirm the acceptable accuracy of er assessment on cnb. the subject needs further investigation in developing countries where omission of the test in surgical samples can be cost and time-saving. background diagnosis of breast cancer is completed through core needle biopsy (cnb) of the tumors but there is controversy on the accuracy of hormone receptor results on cnb specimens.

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Journal title:
iranian red crescent medical journal

جلد ۱۵، شماره ۶، صفحات ۵۱۵-۵۱۸

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